Optimization of square microneedle arrays for increasing drug permeability in skin
نویسندگان
چکیده
منابع مشابه
Optimization of square microneedle arrays for increasing drug permeability in skin
Microneedles array is a new transdermal drug delivery technique designed to create holes in 15 the epidermis and penetrate the stratum corneum, thus avoiding the high resistance of this barrier. Microneedles have been shown to increase the skin permeability of drugs with no or little pain. However, the skin permeability of epidermis while using microneedle arrays has yet to be fully studied. In...
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Background and Aim: Drug delivery through the microneedle array has been considered as an easy and non-invasive method in recent years. The purpose of this study was to design and construct an array of biodegradable polymeric microneedles containing Amphotericin-B to introduce this system and its use in the treatment of cutaneous lesions caused by Leishmania major parasite inoculation as a mode...
متن کاملOptimising microneedle arrays to increase skin permeability for transdermal delivery of drugs
Improving drug permeability in skin is considered as one of the most important issues for designing new methods of transdermal drug delivery. Consequently, many techniques have been proposed to more effectively deliver drugs across the stratum corneum, including chemical enhancers or physical enhancer techniques, e.g., iontophoresis and ultrasound. Standard hypodermic injection is an effective ...
متن کاملOptimizing microneedle arrays for transdermal drug delivery: extension to non-square distribution of microneedles.
The technology of fabricating microneedle arrays to deliver high molecular weight drugs across skin in a minimally invasive manner is receiving increasing attention. Microneedle arrays with different geometries have been manufactured using materials such as glass, polymer, metal, etc. However, a framework that can identify the optimum designs of these arrays seems to be lacking. This is importa...
متن کاملCharacterization of Polymeric Microneedle Arrays for Transdermal Drug Delivery
Microfabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays (MNs) were extensively investigated based in a nano sensitive fabrication style known as micromilling that is then combined with conventional micromolding technique. The aim of this study was to describe the polymer selection, and optimize formulation compounding parameters for various polymeric MNs. Inve...
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ژورنال
عنوان ژورنال: Chemical Engineering Science
سال: 2008
ISSN: 0009-2509
DOI: 10.1016/j.ces.2008.02.007